Our Research and Techniques

Neuroscience is going through a major technical revolution. Our lab uses and develops novel optical, electrophysiological, and genetic tools that allow to record neural activity from thousands of neurons across many different brain regions at the same time, while selectively turning 'ON' or 'OFF' specific neurons during behavior. This gives an opportunity for the first time to look inside the neural fabric that constitutes thoughts, emotions, and memories.
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'Reading' and 'Writing' from/into the brain by Optogenetic stimulation of individual neurons combined with Optical Imaging of neural activity
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  • Measuring effective connectivity in vivo
  • Manipulating behavior
  • Studying how the memory trace changes during learning
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Studying decision-making processes

Learning?

  • Studying decision-making processes
  • Changes in neural code during learning
  • Neural basis for short-term memory
  • Formation of long-term memory
  • Neural representation for motor space
Mesoscale imaging of neural activity at single-neuron resolution during behavior
  • Functional maps of the brain at single cell resolution
  • Information flow across different brain regions during behavior
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Simultaneous imaging of 30,000 individual neurons, across ~10 cortical regions during behavior
How does network connectivity and function change following stroke and other forms of neurodegeneration?
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Ablation of specific neurons
  • Mechanisms of network reorganization following stroke and after damage to specific neurons?
  • Can brain stimulation facilitate recovery following stroke?
Photo-thrombotic stroke
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